Fat Embolism Syndrome
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چکیده
The initial symptoms are probably caused by mechanical occlusion of multiple blood vessels with fat globules that are too large to pass through the capillaries. The vascular occlusion in fat embolism is often temporary or incomplete, as fat globules do not obstruct capillary blood flow completely because of their fluidity and deformability. The late presentation is thought to be a result of hydrolysis of the fat to more irritating free fatty acids which then migrate to other organs via the systemic circulation. In the lungs, for example, there is direct toxicity to the lung tissue or capillary endothelium. [3] It has also been suggested that paradoxical embolism occurs from shunting. [3]
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